KHN Video: Warrior Luke

The Orphan Drug Machine

By Heidi de Marco

Feb. 6, 2017

KHN’s coverage of prescription drug development, costs and pricing is supported in part by the .

We Want To Hear From You

Do you have a question or comment for the 51��Ƶ Health News team?

More from 51��Ƶ Health News

President Trump speaks at a podium. The American flag is to the left of him. A flag with the presidential seal is to the right of him. Behind him is a sign that reads, "TrumpRx.gov."

Trump Promised Cheaper Drugs. Some Prices Dropped. Many Others Shot Up.

For all of President Donald Trump’s showmanship, the share of Americans his policies will likely help remains slim, even if some patients do come out ahead.

By Elisabeth Rosenthal and Arthur Allen May 7, 2026

A hand-drawn illustration of a hand holding a GLP-1 injector that has a note attached to it, which reads, "GLP-1 APPROVED!"

Trouble Getting Weight Loss Drugs Covered by Insurance? Here’s What To Know

By Sydney Lupkin June 26, 2026

A close-up photograph of Marty Makary speaking into a microphone at a podium.

FDA’s Plan To Boost Biosimilar Drugs Could Stall at the Patent Office

By Arthur Allen Nov. 17, 2025

A photo illustration showing a brain and a child's face. Above it is the chemical 51��Ƶ for leucovorin.

Off-Label Drug Helps One Boy With Autism Speak, Parents Say. But Experts Want More Data.

By Céline Gounder Sept. 26, 2025

51��Ƶ

Trump 2.0

Public Health

Audio Reports

Special Reports